Description
Product Characteristics:
ZGPAT is a 531 amino acid protein that contains a G-patch domain, which is typically found within RNA-binding proteins. Proteins that contain the G-patch domain include some tumor suppressor and DNA-damage repair proteins. ZGPAT also contains one C3H1-type zinc finger, which further supports its probable role as an RNA-binding protein. The gene encoding ZGPAT is inactivated via differential methylation in a oligodendroglioma cell line, suggesting that ZGPAT may have utility as a biomarker. There are two isoforms of ZGPAT that are produced as a result of alternative splicing events.
Subcellular location: Nucleus
Synonyms: dJ583P15.3, FLJ14972, G patch domain-containing protein 6, GPATC6, GPATCH6, KIAA1847, MGC44880, RP4 583P15.3, ZC3H9, ZC3HDC9, ZGPAT, ZGPAT_HUMAN, Zinc finger and G patch domain-containing protein, Zinc finger CCCH domain-containing protein 9, Zinc finger CCCH type with G patch domain1, Zinc finger CCCH-type with G patch domain-containing protein, ZIP.
Target Information: Transcription repressor that specifically binds the 5'- GGAG[GA]A[GA]A-3' consensus sequence. Represses transcription by recruiting the chromatin multiprotein complex NuRD to target promoters. Negatively regulates expression of EGFR, a gene involved in cell proliferation, survival and migration (By similarity)